MRFF – CTA Initiative – 2025 Clinical Trials Activity Grant Opportunity

# ⚕️ MRFF – CTA Initiative – 2025 Clinical Trials Activity Grant Opportunity The National Health and Medical Research Council (NHMRC), on behalf of the Australian Government Department of Health and Aged Care, is offering the **Medical Research Future Fund (MRFF) – 2025 Clinical Trials Activity Grant Opportunity**. This initiative aims to enhance the **evidence base for clinical care**, improve **patient access to trials**, and facilitate the integration of **international clinical trials** in Australia. The total available funding for this opportunity is **$61,000,000**. ## 🎯 Objectives & Research Streams This grant seeks to fund **medical research and innovation projects** across four distinct streams: * **Stream 1 (Incubator):** Pilot studies assessing the feasibility of new clinical trials for **rare cancers, rare diseases, or unmet needs**. * **Stream 2 (Targeted Call):** Clinical trials for treatments/management of **rare cancers, rare diseases, or unmet needs**. * **Stream 3 (Targeted Call):** Clinical trials addressing **evidence gaps** relevant to **health technology assessment processes** for effective and high-value care. * **Stream 4 (Targeted Call):** **Prevention clinical trials** focused on reducing disease risk, onset, or progression through **early intervention**. The overarching goal is to improve the **health and wellbeing of Australians** through high-quality, evidence-based healthcare. ## 🤝 Eligibility & Application This is a **Targeted or Restricted Competitive** grant. Applications are strictly limited to **approved MRFF Eligible Organisations** as listed on the NHMRC website. All applications must adhere to the detailed **Medical Research Future Fund – Clinical Trials Activity Initiative - 2025 Clinical Trials Activity Grant Opportunity Guidelines**. ### 🗓️ Key Dates: * **Minimum Data Close:** 5:00 PM (ACT Local Time) on 4 March 2026. * **Questions Submission Deadline:** 1:00 PM (ACT Local Time) on 25 March 2026. Applicants must submit electronically via **NHMRC’s online granting system (Sapphire)**. It is highly recommended to liaise with the submitting MRFF Eligible Organisation for specific internal requirements. **Keywords:** Medical Research Future Fund, MRFF, Clinical Trials, Health Research Grants, Medical Innovation, Rare Cancers, Rare Diseases, Unmet Needs, Prevention Trials, Health Technology Assessment, Australia, NHMRC, Government Grants, Healthcare Funding, Research Funding, Early Intervention.